Triggering cryptic natural product biosynthesis in microorganisms

被引：428

作者：

Scherlach, Kirstin ^{[1
]}

Hertweck, Christian ^{[1
]}

机构：

[1] Leibniz Inst Nat Prod Res & Infect Biol HKI, D-07745 Jena, Germany

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 09期

关键词：

COMPLETE GENOME SEQUENCE; STREPTOMYCES-COELICOLOR; METABOLITE PRODUCTION; GENE-CLUSTER; JADOMYCIN-B; VIRULENCE DETERMINANTS; BACTERIAL ENDOSYMBIONT; SECONDARY METABOLITES; POLYKETIDE SYNTHASES; ASPERGILLUS-NIDULANS;

D O I：

10.1039/b821578b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Natural products from microorganisms are a crucial source for novel therapeutics. Even so, it seems that many valuable compounds are overlooked when culturing microbes under standardized laboratory conditions. Many biosynthesis genes remain silent and such "cryptic" or "orphan" pathways are only activated under specific conditions. This report gives an overview on the strategies to trigger biosynthetic pathways to yield "cryptic natural products" through external cues, co-cultivation and genomic approaches such as genome-mining, epigenetic remodeling, and engineered pathway activation.

引用

页码：1753 / 1760

页数：8

共 78 条

[1] HORMAOMYCIN, A NOVEL PEPTIDE LACTONE WITH MORPHOGENETIC ACTIVITY ON STREPTOMYCES .252. [J].

ANDRES, N ;

WOLF, H ;

ZAHNER, H ;

ROSSNER, E ;

ZEECK, A ;

KONIG, WA ;

SINNWELL, V .

HELVETICA CHIMICA ACTA, 1989, 72 (03) :426-437

[2] Pyocyanin isolated from a marine microbial population: Synergistic production between two distinct bacterial species and mode of action [J].

Angell, Scott ;

Bench, Bennie J. ;

Williams, Howard ;

Watanabe, Coran M. H. .

CHEMISTRY & BIOLOGY, 2006, 13 (12) :1349-1359

[3] JADOMYCIN, A NOVEL 8H-BENZ[B]OXAZOLO[3,2-F]PHENANTHRIDINE ANTIBIOTIC FROM STREPTOMYCES-VENEZUELAE ISP5230 [J].

AYER, SW ;

MCINNES, AG ;

THIBAULT, P ;

WALTER, JA ;

DOULL, JL ;

PARNELL, T ;

VINING, LC .

TETRAHEDRON LETTERS, 1991, 32 (44) :6301-6304

[4] Isolation and identification of three new 5-alkenyl-3,3(2H)-furanones from two Streptomyces species using a genomic screening approach [J].

Banskota, AH ;

McAlpine, JB ;

Sorensen, D ;

Aouidate, M ;

Piraee, M ;

Alarco, AM ;

Omura, S ;

Shiomi, K ;

Farnet, CM ;

Zazopoulos, E .

JOURNAL OF ANTIBIOTICS, 2006, 59 (03) :168-176

[5] Genomic analyses lead to novel secondary metabolites [J].

Banskota, Arjun H. ;

McAlpine, James B. ;

Sorensen, Dan ;

Ibrahim, Ashraf ;

Aouidate, Mustapha ;

Piraee, Mahmood ;

Alarco, Anne-Marie ;

Farnet, Chris M. ;

Zazopoulos, Emmanuel .

JOURNAL OF ANTIBIOTICS, 2006, 59 (09) :533-542

[6] Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2) [J].

Bentley, SD ;

Chater, KF ;

Cerdeño-Tárraga, AM ;

Challis, GL ;

Thomson, NR ;

James, KD ;

Harris, DE ;

Quail, MA ;

Kieser, H ;

Harper, D ;

Bateman, A ;

Brown, S ;

Chandra, G ;

Chen, CW ;

Collins, M ;

Cronin, A ;

Fraser, A ;

Goble, A ;

Hidalgo, J ;

Hornsby, T ;

Howarth, S ;

Huang, CH ;

Kieser, T ;

Larke, L ;

Murphy, L ;

Oliver, K ;

O'Neil, S ;

Rabbinowitsch, E ;

Rajandream, MA ;

Rutherford, K ;

Rutter, S ;

Seeger, K ;

Saunders, D ;

Sharp, S ;

Squares, R ;

Squares, S ;

Taylor, K ;

Warren, T ;

Wietzorrek, A ;

Woodward, J ;

Barrell, BG ;

Parkhill, J ;

Hopwood, DA .

NATURE, 2002, 417 (6885) :141-147

[7] Bioactive microbial metabolites -: A personal view [J].

Bérdy, J .

JOURNAL OF ANTIBIOTICS, 2005, 58 (01) :1-26

[8] Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans [J].

Bergmann, Sebastian ;

Schuemann, Julia ;

Scherlach, Kirstin ;

Lange, Corinna ;

Brakhage, Axel A. ;

Hertweck, Christian .

NATURE CHEMICAL BIOLOGY, 2007, 3 (04) :213-217

[9] Enhancement of antibiotic and secondary metabolite detection from filamentous fungi by growth on nutritional arrays [J].

Bills, G. F. ;

Platas, G. ;

Fillola, A. ;

Jimenez, M. R. ;

Collado, J. ;

Vicente, F. ;

Martin, J. ;

Gonzalez, A. ;

Bur-Zimmermann, J. ;

Tormo, J. R. ;

Pelaez, F. .

JOURNAL OF APPLIED MICROBIOLOGY, 2008, 104 (06) :1644-1658

[10]

BODE BH, 2000, EUR J ORG CHEM, P1451

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