Silicon nanocrystals as photosensitizers of active oxygen for biomedical applications

被引：83

作者：

Timoshenko, V. Yu. ^{[1
]}

Kudryavtsev, A. A.

Osminkina, L. A.

Vorontsov, A. S.

Ryabchikov, Yu. V.

Belogorokhov, I. A.

Kovalev, D.

Kashkarov, P. K.

机构：

[1] Moscow MV Lomonosov State Univ, Fac Phys, Moscow 119992, Russia

[2] Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142290, Moscow Region, Russia

[3] Univ Bath, Dept Phys, Bath BA2 7AY, Avon, England

来源：

JETP LETTERS | 2006年 / 83卷 / 09期

关键词：

D O I：

10.1134/S0021364006090128

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Silicon nanocrystals dispersed in water have been used to photosensitize the generation of active oxygen. The photosensitizing efficiency has been estimated through the quenching of the exciton photoluminescence of silicon nanocrystals. Experiments have revealed a strong (up to 80%) decrease in the number of cancer mouse fibroblast cells when they come into contact with photoexcited silicon nanocrystals. The obtained results show that the use of silicon nanocrystals for biomedical applications, in particular, for photodynamic therapy of cancer, is feasible.

引用

页码：423 / 426

页数：4

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