Specification of auditory sensitivity by Drosophila TRP channels

被引：114

作者：

Goepfert, Martin C. ^{[1
]}

Albert, Joerg T. ^{[1
]}

Nadrowski, B. ^{[1
]}

Kamikouchi, A. ^{[1
]}

机构：

[1] Univ Cologne, Inst Zool, Volkswagen Fdn Res Grp, D-50923 Cologne, Germany

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 08期

关键词：

D O I：

10.1038/nn1735

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ears achieve their exquisite sensitivity by means of mechanical feedback: motile mechanosensory cells through their active motion boost the mechanical input from the ear. Examination of the auditory mechanics in Drosophila melanogaster mutants shows that the transient receptor potential (TRP) channel NompC is required to promote this feedback, whereas the TRP vanilloid (TRPV) channels Nan and Iav serve to control the feedback gain. The combined function of these channels specifies the sensitivity of the fly auditory organ.

引用

页码：999 / 1000

页数：2

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