INDOLE ALKALOIDS FROM THE LEAVES OF ALSTONIA SCHOLARIS

被引：14

作者：

Hirasawa, Yusuke ^{[1
]}

Miyama, Saori ^{[1
]}

Kawahara, Nobuo ^{[2
]}

Goda, Yukihiro ^{[2
]}

Rahman, Abdul ^{[3
]}

Ekasari, Wiwied ^{[3
]}

Widyawaruyanti, Aty ^{[3
]}

Indrayanto, Gunawan ^{[3
]}

Zaini, Noor Cholies ^{[3
]}

Morita, Hiroshi ^{[1
]}

机构：

[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan

[2] Natl Inst Hlth Sci, Setagaya Ku, Tokyo 1588501, Japan

[3] Airlangga Univ, Jalan Dharmawangsa Dalam 60286, Surabaya, Indonesia

来源：

HETEROCYCLES | 2009年 / 79卷

关键词：

Alstonia scholaris; Akuammidine-N-oxide; Akuammidine; Antiplasmodial Activity; KOPSIA-FLAVIDA BLUME; PARASITES; THAILAND; DRUGS;

D O I：

10.3987/COM-08-S(D)65

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

A new indole alkaloid, akuammidine-N-oxide (1) was isolated from the leaves of Alstonia scholaris (Apocynaceae) together with akuammidine (2), and the structure was elucidated by NMR spectral analysis and chemical correlation. Akuammidine (2) showed a moderate antiplasmodial activity.

引用

页码：1107 / 1112

页数：6

共 13 条

[1]

ALKALOIDS OF ALSTONIA-SCHOLARIS FROM THAILAND [J].

BOONCHUAY, W ;

COURT, WE .

PLANTA MEDICA, 1976, 29 (04) :380-390

[2]

Parasitology - Drugs to combat tropical protozoan parasites [J].

Gelb, MH ;

Hol, WGJ .

SCIENCE, 2002, 297 (5580) :343-344

[3]

Two new methyl chanofruticosinates from Kopsia flavida Blume [J].

Husain, K ;

Jantan, I ;

Said, IM ;

Aimi, N ;

Takayama, H .

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2003, 5 (01) :63-67

[4]

Methyl chanofruticosinates from leaves of Kopsia flavida blume [J].

Husain, K ;

Jantan, I ;

Kamaruddin, N ;

Said, IM ;

Aimi, N ;

Takayama, H .

PHYTOCHEMISTRY, 2001, 57 (04) :603-606

[5]

Evaluation of anticancer activity of the alkaloid fraction of Alstonia scholaris (Sapthaparna) in vitro and in vivo [J].

Jagetia, GC ;

Baliga, MS .

PHYTOTHERAPY RESEARCH, 2006, 20 (02) :103-109

[6]

Antiplasmodial activity of extracts and alkaloids of three Alstonia species from Thailand [J].

Keawpradub, N ;

Kirby, GC ;

Steele, JCP ;

Houghton, PJ .

PLANTA MEDICA, 1999, 65 (08) :690-694

[7]

Antibacterial activity of Alstonia scholaris and Leea tetramera [J].

Khan, MR ;

Omoloso, AD ;

Kihara, M .

FITOTERAPIA, 2003, 74 (7-8) :736-740

[8]

Alstilobanines A-E, new indole alkaloids from Alstonia angustiloba [J].

Koyama, Koichiro ;

Hirasawa, Yusuke ;

Zaima, Kazumasa ;

Hoe, Teh Chin ;

Chan, Kit-Lam ;

Morita, Hiroshi .

BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (13) :6483-6488

[9]

SEKAR PKN, 1991, BIOCHEM INT, V25, P491

[10]

Sekiguchi M, 2008, HETEROCYCLES, V75, P2283

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