Antimicrobial activity of polycationic peptides

被引：62

作者：

Giacometti, A ^{[1
]}

Cirioni, O ^{[1
]}

Barchiesi, F ^{[1
]}

Del Prete, MS ^{[1
]}

Scalise, G ^{[1
]}

机构：

[1] Univ Ancona, Inst Infect Dis & Publ Hlth, I-60121 Ancona, Italy

来源：

PEPTIDES | 1999年 / 20卷 / 11期

关键词：

bacteria; yeasts; protozoa; susceptibility tests;

D O I：

10.1016/S0196-9781(99)00131-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The in vitro activity of six polycationic peptides, buforin II, cecropin P1, indolicidin, magainin II, nisin, and ranalexin, were evaluated against several clinical isolates of Gram-positive and Gram-negative aerobic bacteria, yeasts, Pneumocystis carinii and Cryptosporidium parvum, by using microbroth dilution methods. The peptides exhibited different antibacterial activities and rapid time-dependent killing. The Gram-negative organisms were more susceptible to buforin II and cecropin P1, whereas buforin II and ranalexin were the most active compounds against the Gram-positive strains. Similarly, ranalexin showed the highest activity against Candida spp., whereas magainin II exerted the highest anticryptococcal activity. Finally, the peptides showed high anti-Pneumocystis activity, whereas no compound had strong inhibitory effect on C. parvum. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：1265 / 1273

页数：9

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