Specific accumulation of γ- and δ-tocotrienols in tumor and their antitumor effect in vivo

被引：43

作者：

Hiura, Yuhei ^{[1
]}

Tachibana, Hirofumi ^{[1
,2
]}

Arakawa, Ryo ^{[1
]}

Aoyama, Natsuki ^{[1
]}

Okabe, Masaaki ^{[1
]}

Sakai, Midori ^{[1
]}

Yamada, Koji ^{[1
]}

机构：

[1] Kyushu Univ, Dept Biosci & Biotechnol, Fac Agr, Lab Food Chem,Div Appl Biol Chem, Fukuoka 8128581, Japan

[2] Kyushu Univ, Bioarchitecture Ctr, Dept Funct Metab Design, Lab Funct Food Design, Fukuoka 8128581, Japan

来源：

JOURNAL OF NUTRITIONAL BIOCHEMISTRY | 2009年 / 20卷 / 08期

关键词：

Tocotrienols; Antitumor; Accumulation; Murine hepatoma MH134 cells; Apoptosis; HEPATOMA DRLH-84 CELLS; SPRAGUE-DAWLEY RATS; CONJUGATED LINOLEIC-ACID; VITAMIN-E ANALOGS; ALPHA-TOCOPHEROL; TISSUE CONCENTRATIONS; IMMUNE FUNCTION; RICH FRACTION; CANCER CELLS; PALM OIL;

D O I：

10.1016/j.jnutbio.2008.06.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

In contrast to extensive studies on tocopherols, very little is understood about tocotrienols (T3). We evaluated the antitumor activities of gamma-T3 and delta-T3 in murine hepatoma MH134 cells in vitro and in vivo. We found that delta-T3 inhibited the growth of MH134 cells more strongly than gamma-T3 by inducing apoptosis. In C3H/HeN mice implanted with MH134, it was found that gamma-T3 and delta-T3 feeding significantly delayed tumor growth. On the other hand, both T3 had no significant effect on body weight, normal-tissue weight and immunoglobulin levels. Intriguingly, we found that T3 was detected in tumor, but not in normal tissues. These results, to our knowledge, are the first demonstration of specific accumulation of gamma-T3 and delta-T3 in tumors and suggest that T3 accumulation is critical for the antitumor activities of T3. (C) 2009 Elsevier Inc. All fights reserved.

引用

页码：607 / 613

页数：7

共 36 条

[1]

Cytochrome P450-dependent metabolism of vitamin E isoforms is a critical determinant of their tissue concentrations in rats [J].