Synthesis and evaluation of fluorine-18 labelled compounds for imaging of bacterial infections with pet

被引：28

作者：

Zijlstra, S.

Gunawan, J.

Freytag, C.

Burchert, W.

机构：

[1] Ruhr Univ Bochum, Univ Klin, Inst Mol Biophys Radiopharm & Nuklearmed, Herz & Diabeteszentrum Nordhein Westfalen, D-32545 Bad Oeynhausen, Germany

[2] Ruhr Univ Bochum, Univ Klin, Inst Labs & Transfusionsmed, Herz & Diabeteszentrum Nordhein Westfalen, D-32545 Bad Oeynhausen, Germany

来源：

APPLIED RADIATION AND ISOTOPES | 2006年 / 64卷 / 07期

关键词：

D O I：

10.1016/j.apradiso.2006.02.095

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Syntheses of no carrier added (n.c.a.) 6-fluoro-1,4-dihydro-1-cyclopropyl-4-oxo-7-[4-[F-18]fluoro-phenacyl-1-piperacinyl]-chinolincarboxylic acid ([F-18]COPCA) and n.c.a. 4-[F-18]fluoro-benzoyl-ubiquicidin 29-41 ([F-18]UBI 29-41) are described. [18F]COPCA was synthesised within 120 min with a radiochemical yield of 9-12%. [F-18]UBI 29-41 was synthesised within 150 min with a radiochemical yield of 15-20%. Both compounds had a specific activity of more than 35 GBq/mu mol. The biological activity was verified by measuring its binding to Staphylococcus aureus bacteria. Specific binding was found for [F-18]UBI 29-41 (12-17%), whereas no specific binding for [F-18]COPCA was found. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：802 / 807

页数：6

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