Baseline quality of life predicts survival in patients with advanced colorectal cancer

被引：187

作者：

Maisey, NR ^{[1
]}

Norman, A ^{[1
]}

Watson, M ^{[1
]}

Allen, MJ ^{[1
]}

Hill, ME ^{[1
]}

Cunningham, D ^{[1
]}

机构：

[1] Royal Marsden Hosp, Dept Med, Sutton SM2 5PT, Surrey, England

来源：

EUROPEAN JOURNAL OF CANCER | 2002年 / 38卷 / 10期

关键词：

colorectal cancer; quality of life; prognosis; clinical trials;

D O I：

10.1016/S0959-8049(02)00098-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of this study was to investigate the influence of baseline quality of life (QoL) on survival in patients with advanced colorectal cancer. From 1992 to 1998, four randomised clinical trials in advanced colorectal cancer were conducted at this institution, The European Organization for Research and Treatment of Cancer-Quality of Life Core 30 (EORTC-QLQ-C30) questionnaire was completed prior to the commencement of chemotherapy. Analyses were performed on median-dichotomised baseline Quality of Life (QoL) and clinical prognostic factors. Baseline QoL questionnaires were completed by 501 patients. One-year survival was 38.3 and 72.5% (P<0.0001) for patients with global QoL scores below and above the median (67), respectively. Other than cognitive functioning, fatigue, appetite, constipation, diarrhoea and financial domains, all QoL scales were significant independent predictors of survival (P<0.035). In the final model, the global QoL score remained highly significant as an independent predictor of survival (P<0.0001). Baseline QoL is a strong independent predictor of survival in patients with advanced colorectal cancer. Measurements should be routinely recorded in clinical trials to stratify cohorts and aid in trial comparison. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1351 / 1357

页数：7

共 46 条

[11] Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer [J].

Cunningham, D ;

Pyrhönen, S ;

James, RD ;

Punt, CJA ;

Hickish, TF ;

Heikkila, R ;

Johannesen, TB ;

Starkhammar, H ;

Topham, CA ;

Awad, L ;

Jacques, C ;

Herait, P .

LANCET, 1998, 352 (9138) :1413-1418

[12]

Dancey J, 1997, QUAL LIFE RES, V6, P151

[13] Relation between tumor size, quality of life, and survival in patients with colorectal liver metastases [J].

Earlam, S ;

Glover, C ;

Fordy, C ;

Burke, D ;

AllenMersh, TG .

JOURNAL OF CLINICAL ONCOLOGY, 1996, 14 (01) :171-175

[14] A RANDOMIZED STUDY OF ORAL NUTRITIONAL SUPPORT VERSUS AD-LIB NUTRITIONAL INTAKE DURING CHEMOTHERAPY FOR ADVANCED COLORECTAL AND NON-SMALL-CELL LUNG-CANCER [J].

EVANS, WK ;

NIXON, DW ;

DALY, JM ;

ELLENBERG, SS ;

GARDNER, L ;

WOLFE, E ;

SHEPHERD, FA ;

FELD, R ;

GRALLA, R ;

FINE, S ;

KEMENY, N ;

JEEJEEBHOY, KN ;

HEYMSFIELD, S ;

HOFFMAN, FA .

JOURNAL OF CLINICAL ONCOLOGY, 1987, 5 (01) :113-124

[15]

FAWZY FI, 1993, ARCH GEN PSYCHIAT, V50, P681

[16] PROTRACTED VENOUS INFUSION 5-FLUOROURACIL AND INTERFERON-ALPHA IN ADVANCED AND REFRACTORY COLORECTAL-CANCER [J].

FINDLAY, M ;

HILL, A ;

CUNNINGHAM, D ;

NORMAN, A ;

NICOLSON, M ;

FORD, H ;

HUSBAND, J ;

EVANS, C ;

CARTER, R .

ANNALS OF ONCOLOGY, 1994, 5 (03) :239-243

[17]

GANZ PA, 1991, CANCER, V67, P3131, DOI 10.1002/1097-0142(19910615)67:12<3131::AID-CNCR2820671232>3.0.CO

[18]

2-4

[19] Chemotherapy improves survival and quality of life in advanced pancreatic and biliary cancer [J].

Glimelius, B ;

Hoffman, K ;

Sjoden, PO ;

Jacobsson, G ;

Sellstrom, H ;

Enander, LK ;

Linne, T ;

Svensson, C .

ANNALS OF ONCOLOGY, 1996, 7 (06) :593-600

[20]

GOODWIN PJ, 2000, P AM SOC CLIN ONCOL, V20, pA21

← 1 2 3 4 5 →