Genomic medicine and the future of health care

被引：116

作者：

Sander, C

机构：

[1] Millennium Pharmaceut & Millennium Predict Med, Cambridge, MA 02139 USA

[2] MIT, Ctr Genome Res, Cambridge, MA 02139 USA

来源：

SCIENCE | 2000年 / 287卷 / 5460期

关键词：

D O I：

10.1126/science.287.5460.1977

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Genomic technologies and computational advances are Leading to an information revolution in biology and medicine. Simulations of molecular processes in cells and predictions of drug effects in humans will advance pharmaceutical research and speed up clinical trials. Computational prognostics and diagnostics that combine clinical data with genotyping and molecular profiling may soon cause fundamental changes in the practice of health care.

引用

页码：1977 / 1978

页数：2

共 17 条

[1] Alliance of US labs plans to build map of cell signalling pathways
Abbott, A
[J]. NATURE, 1999, 402 (6759) : 219 - 220
[2] Arkin A, 1998, GENETICS, V149, P1633
[3] BRAZMA A, COMMUNICATION
[4] Genomic biology
Brent, R
[J]. CELL, 2000, 100 (01) : 169 - 183
[5] Exploring the new world of the genome with DNA microarrays
Brown, PO
Botstein, D
[J]. NATURE GENETICS, 1999, 21 (Suppl 1) : 33 - 37
[6] Computational methods for the prediction of 'drug-likeness'
Clark, DE
Pickett, SD
[J]. DRUG DISCOVERY TODAY, 2000, 5 (02) : 49 - 58
[7] Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
Golub, TR
Slonim, DK
Tamayo, P
Huard, C
Gaasenbeek, M
Mesirov, JP
Coller, H
Loh, ML
Downing, JR
Caligiuri, MA
Bloomfield, CD
Lander, ES
[J]. SCIENCE, 1999, 286 (5439) : 531 - 537
[8] Protein biochemistry - Protein interaction methods - Toward an endgame
Mendelsohn, AR
Brent, R
[J]. SCIENCE, 1999, 284 (5422) : 1948 - 1950
[9] MUIR CS, COMMUNICATION
[10] Schaff J, 1999, Pac Symp Biocomput, P228

← 1 2 →