Genomic medicine and the future of health care

被引：116

作者：

Sander, C

机构：

[1] Millennium Pharmaceut & Millennium Predict Med, Cambridge, MA 02139 USA

[2] MIT, Ctr Genome Res, Cambridge, MA 02139 USA

来源：

SCIENCE | 2000年 / 287卷 / 5460期

关键词：

D O I：

10.1126/science.287.5460.1977

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Genomic technologies and computational advances are Leading to an information revolution in biology and medicine. Simulations of molecular processes in cells and predictions of drug effects in humans will advance pharmaceutical research and speed up clinical trials. Computational prognostics and diagnostics that combine clinical data with genotyping and molecular profiling may soon cause fundamental changes in the practice of health care.

引用

页码：1977 / 1978

页数：2

共 17 条

[11] Microarrays: biotechnology's discovery platform for functional genomics
Schena, M
Heller, RA
Theriault, TP
Konrad, K
Lachenmeier, E
Davis, RW
[J]. TRENDS IN BIOTECHNOLOGY, 1998, 16 (07) : 301 - 306
[12] Service RF, 1999, SCIENCE, V284, P80
[13] Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization
Spellman, PT
Sherlock, G
Zhang, MQ
Iyer, VR
Anders, K
Eisen, MB
Brown, PO
Botstein, D
Futcher, B
[J]. MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (12) : 3273 - 3297
[14] E-CELL: software environment for whole-cell simulation
Tomita, M
Hashimoto, K
Takahashi, K
Shimizu, TS
Matsuzaki, Y
Miyoshi, F
Saito, K
Tanida, S
Yugi, K
Venter, JC
Hutchison, CA
[J]. BIOINFORMATICS, 1999, 15 (01) : 72 - 84
[15] A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae
Uetz, P
Giot, L
Cagney, G
Mansfield, TA
Judson, RS
Knight, JR
Lockshon, D
Narayan, V
Srinivasan, M
Pochart, P
Qureshi-Emili, A
Li, Y
Godwin, B
Conover, D
Kalbfleisch, T
Vijayadamodar, G
Yang, MJ
Johnston, M
Fields, S
Rothberg, JM
[J]. NATURE, 2000, 403 (6770) : 623 - 627
[16] WEINSTEIN JN, 1999, NAT GENET, V23, P81
[17] Mass spectrometry - from genomics to proteomics
Yates, JR
[J]. TRENDS IN GENETICS, 2000, 16 (01) : 5 - 8

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