Sepsis and Septic Shock: A History

被引：103

作者：

Funk, Duane J.

Parrillo, Joseph E. ^{[2
]}

Kumar, Anand ^{[1
,3
]}

机构：

[1] Univ Manitoba, Sect Infect Dis Med Microbiol & Pharmacol Therape, Sect Crit Care Med, Winnipeg, MB R3T 2N2, Canada

[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Med, Cooper Univ Hosp,Cooper Heart Inst, Camden, NJ 08103 USA

[3] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Infect Dis Sect, Sect Crit Care Med, Camden, NJ 08103 USA

来源：

CRITICAL CARE CLINICS | 2009年 / 25卷 / 01期

关键词：

Sepsis; Septic shock; History; Endotoxin; Cytokines; Coagulaiton; Nitric oxide; Sepsis hemodynamics; ACTIVATED PROTEIN-C; RANDOMIZED CONTROLLED-TRIAL; ARTERIAL SMOOTH-MUSCLE; NITRIC-OXIDE; MYOCARDIAL DYSFUNCTION; VIRUS INTERFERENCE; ANTITHROMBIN-III; RELAXING FACTOR; RELAXATION; CACHECTIN;

D O I：

10.1016/j.ccc.2008.12.003

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Infectious disease has been a leading cause of death in humans since the first recorded tabulations. From Hippocrates and Galen, to Lister, Fleming and Semmelweiss, this article reviews the notable historical figures of sepsis research. The early descriptions and theories about the etiology (microbial pathogens), pathogenesis (toxins and mediators), and treatment of sepsis-associated disease are also discussed.

引用

页码：83 / +

页数：20

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