Total synthesis of nothapodytine B and (±)-mappicine

被引：32

作者：

Chavan, SP ^{[1
]}

Sivappa, R ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem Technol, Pune 411008, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 20期

关键词：

total synthesis; nothapodytine B; mappicine; Johnson orthoester rearrangement; pyridon;

D O I：

10.1016/j.tetlet.2004.03.089

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel, efficient total synthesis of the naturally occurring antiviral nothapodytine B (2, mappicine ketone) is reported. The approach is based on the successful implementation of the Johnson orthoester rearrangement of allylic alcohol 7 for assembly of a pyridone D ring precursor with the necessary functionalities. Nothapodytine B is converted into mappicine 3 by NaBH4 reduction. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3941 / 3943

页数：3

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