Cu(I)-catalyzed direct addition and asymmetric addition of terminal alkynes to imines

被引：207

作者：

Wei, CM

Mague, JT

Li, CJ ^{[1
]}

机构：

[1] Tulane Univ, Dept Chem, New Orleans, LA 70118 USA

[2] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2004年 / 101卷 / 16期

关键词：

D O I：

10.1073/pnas.0307150101

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A Cu(I)-catalyzed direct addition of alkynes to imines was developed. The process is simple and provides a diverse range of propargylamines in high enantiomeric excess and good yield both in water and in toluene. The absolute configuration of such addition products has been determined by x-ray crystallography.

引用

页码：5749 / 5754

页数：6

共 68 条

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