IL-1β and IL-2 convert human Treg into TH17 cells

被引：145

作者：

Deknuydt, Florence ^{[1
]}

Bioley, Gilles ^{[1
]}

Valmori, Danila ^{[1
,2
]}

Ayyoub, Maha ^{[1
]}

机构：

[1] CLCC Rene Gauducheau, Inst Natl Sante & Rech Med, U892, F-44800 St Herblain, France

[2] Univ Nantes, Fac Med, F-44093 Nantes, France

来源：

CLINICAL IMMUNOLOGY | 2009年 / 131卷 / 02期

关键词：

Treg; T(H)17; IL-1; beta; IL-2; GROWTH-FACTOR-BETA; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; TOLL-LIKE; TGF-BETA; T-CELLS; CUTTING EDGE; DIFFERENTIATION; EXPRESSION; FOXP3; INTERLEUKIN-1-BETA;

D O I：

10.1016/j.clim.2008.12.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural CD4(+)CD25(+) regulatory T cells (Treg) and interleukin 17 (IL-17)-producing T helper cells (T(H)17) carry out opposite functions, the former maintaining self-tolerance and the latter being involved in inflammation and autoimmunity. We report here that stimulation of human Natural Treg under T(H)17 polarizing conditions in the presence of IL-2 converts them into T(H)17 cells. Conversion of Tregs into T(H)17 cells occurs both from natural naive Tregs (NnTregs) and, to a higher extent, from memory Tregs (MTregs). Among antigen presenting cells, fresh monocytes activated by microbial stimuli were the most efficient inducers of T(H)17 cells from Tregs. Conversion of Treg into T(H)17 cells was induced by IL-1 beta and involved down-regulation of the Treg lineage transcription factor FOXP3 and suppressive functions. Our results indicate that, under inflammatory conditions, in the presence of IL-2, Treg can be converted into pro-inflammatory T(H)17 cells and establish a functional link between inflammation and autoimmunity. (C) 2009 Elsevier Inc. All. rights reserved.

引用

页码：298 / 307

页数：10

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