Antibody engineering

被引：71

作者：

Hayden, MS ^{[1
]}

Gilliland, LK ^{[1
]}

Ledbetter, JA ^{[1
]}

机构：

[1] UNIV OXFORD, SIR WILLIAM DUNN SCH PATHOL, OXFORD OX1 3RE, ENGLAND

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(97)80136-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of recombinant techniques for the rapid cloning, expression, and characterization of cDNAs encoding antibody (Ab) subunits has revolutionized the field of antibody engineering. By fusion to heterologous protein domains, chain shuffling, and inclusion of self-assembly motifs, novel molecules such as bispecific Abs can now be generated which possess the subset of functional properties designed to fit the intended application. Rapid technological developments in phage display of peptides and proteins have led to a plethora of applications directed towards immunology and antibody engineering. Many of the problems associated with the therapeutic use of Abs are being addressed by the application of these new techniques.

引用

页码：201 / 212

页数：12

共 127 条

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