Unique chromatin remodeling and transcriptional regulation in spermatogenesis

被引：362

作者：

Sassone-Corsi, P ^{[1
]}

机构：

[1] Inst Genet & Biol Mol & Cellulaire, F-67404 Strasbourg, France

来源：

SCIENCE | 2002年 / 296卷 / 5576期

关键词：

D O I：

10.1126/science.1070963

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Most of our knowledge of transcriptional regulation comes from studies in somatic cells. However, increasing evidence reveals that gene regulation mechanisms are different in haploid germ cells. A number of highly specialized strategies operate during spermatogenesis. These include a unique chromatin reorganization program and the use of distinct promoter elements and specific transcription factors. Deciphering the rules governing transcriptional control during spermatogenesis will provide valuable insights of biomedical importance.

引用

页码：2176 / 2178

页数：4

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