Unique chromatin remodeling and transcriptional regulation in spermatogenesis

被引：362

作者：

Sassone-Corsi, P ^{[1
]}

机构：

[1] Inst Genet & Biol Mol & Cellulaire, F-67404 Strasbourg, France

来源：

SCIENCE | 2002年 / 296卷 / 5576期

关键词：

D O I：

10.1126/science.1070963

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Most of our knowledge of transcriptional regulation comes from studies in somatic cells. However, increasing evidence reveals that gene regulation mechanisms are different in haploid germ cells. A number of highly specialized strategies operate during spermatogenesis. These include a unique chromatin reorganization program and the use of distinct promoter elements and specific transcription factors. Deciphering the rules governing transcriptional control during spermatogenesis will provide valuable insights of biomedical importance.

引用

页码：2176 / 2178

页数：4

共 36 条

[21] A testis-specific transcription factor IIA (TFIIAτ) stimulates TATA-binding protein-DNA binding and transcription activation [J].

Ozer, J ;

Moore, PA ;

Lieberman, PM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (01) :122-128

[22] PURIFICATION OF THE CENTROMERE-SPECIFIC PROTEIN CENP-A AND DEMONSTRATION THAT IT IS A DISTINCTIVE HISTONE [J].

PALMER, DK ;

ODAY, K ;

TRONG, HL ;

CHARBONNEAU, H ;

MARGOLIS, RL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) :3734-3738

[23] Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification [J].

Roest, HP ;

vanKlaveren, J ;

deWit, J ;

vanGurp, CG ;

Koken, MHM ;

Vermey, M ;

vanRoijen, JH ;

Hoogerbrugge, JW ;

Vreeburg, JTM ;

Baarends, WM ;

Bootsma, D ;

Grootegoed, JA ;

Hoeijmakers, JHJ .

CELL, 1996, 86 (05) :799-810

[24] CREM: a master-switch governing male germ cell differentiation and apoptosis [J].

Sassone-Corsi, P .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 1998, 9 (04) :475-482

[25] Transcriptional checkpoints determining the fate of male germ cells [J].

SassoneCorsi, P .

CELL, 1997, 88 (02) :163-166

[26]

SCHMIDT EE, 1995, DEVELOPMENT, V121, P2373

[27] BEHAVIOR OF XY PAIR IN MAMMALS [J].

SOLARI, AJ .

INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY, 1974, 38 :273-317

[28]

Turner BM, 2000, BIOESSAYS, V22, P836, DOI 10.1002/1521-1878(200009)22:9<836::AID-BIES9>3.3.CO

[29]

2-O

[30] Identification of a general transcription factor TFIIAα/β homolog selectively expressed in testis [J].

Upadhyaya, AB ;

Lee, SH ;

DeJong, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (25) :18040-18048

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