Oligomer synthesis and DNA/RNA recognition properties of a novel oligonucleotide backbone analog: Glucopyranosyl nucleic amide (GNA)

被引：40

作者：

Goodnow, RA

Tam, S

Pruess, DL

McComas, WW

机构：

[1] Roche Research Center, Hoffmann-La Roche, Nutley

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 18期

关键词：

D O I：

10.1016/S0040-4039(97)00611-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general solid phase synthesis is described for the construction of novel amide linked oligonucleotide analogs having the glucopyranosyl configuration via solid phase N-Fmcc-type peptide chemistry. The selective binding to DNA and RNA sequences by these oligomers is characterized by measurement of melting temperatures and related thermodynamic constants. (C) 1997 Elsevier Science Ltd.

引用

页码：3199 / 3202

页数：4

共 14 条

[11] BASE-STACKING AND BASE-PAIRING CONTRIBUTIONS TO HELIX STABILITY - THERMODYNAMICS OF DOUBLE-HELIX FORMATION WITH CCGG, CCGGP, CCGGAP, ACCGGP, CCGGUP, AND ACCGGUP [J].