Applications of homochiral metal-organic frameworks in enantioselective adsorption and chromatography separation

被引：48

作者：

Li, Xianjiang ^{[1
]}

Chang, Cuilan ^{[1
]}

Wang, Xin ^{[1
]}

Bai, Yu ^{[1
]}

Liu, Huwei ^{[1
]}

机构：

[1] Peking Univ, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Inst Analyt Chem,Coll Chem & Mol Engn, Beijing 100871, Peoples R China

来源：

ELECTROPHORESIS | 2014年 / 35卷 / 19期

基金：

中国国家自然科学基金;

关键词：

Chiral separation; Chiral stationary phase; Enantioselective adsorption; Metal-organic frameworks; PERFORMANCE LIQUID-CHROMATOGRAPHY; HIGHLY SELECTIVE SEPARATION; INTRINSIC CHIRAL TOPOLOGY; ACHIRAL BUILDING-BLOCKS; STATIONARY-PHASE; COORDINATION POLYMERS; CAPILLARY ELECTROCHROMATOGRAPHY; ABSOLUTE HELICITY; POROUS SOLIDS; RESOLUTION;

D O I：

10.1002/elps.201400079

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Chiral separation is of great importance for drug development, pharmacology, and biology. Chiral metal-organic frameworks (MOFs) is a new class of porous solid materials with high surface area, large pore size, high chemical stability, uniformly structured cavities, and the availability of modification. The excellent properties of MOFs have attracted intense interest to explore their performance and mechanism in chiral separation. This review summarizes three synthetic strategies of chiral MOFs and their applications in enantioselective adsorption and chromatographic separation. All the experimental and molecular simulation results demonstrated that high enantioselectivity was strongly correlated with a close match between the size of the pore and chiral molecules.

引用

页码：2733 / 2743

页数：11

共 71 条

[1] Postsynthetic Modification Switches an Achiral Framework to Catalytically Active Homochiral Metal-Organic Porous Materials [J].