Synthesis and cardiac effects of 3,4-dihydropyrimidin-2-(1H)-one-5 carboxylates

被引：60

作者：

Sujatha, Kuppusamy

Shanmugam, Pachaiyappan

Perumal, Paramasivam T. ^{[1
]}

Muralidharan, Doraisamy

Rajendran, Melani

机构：

[1] Sri Ramachandra Med Coll & Res Inst, Sri Ramachandra Coll Pharm, Madras 600116, Tamil Nadu, India

[2] Cent Leather Res Inst, Div Organ Chem, Madras 600020, Tamil Nadu, India

[3] Sri Ramachandra Med Coll & Res Inst, Dept Anat, Madras 600116, Tamil Nadu, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 18期

关键词：

cardiovascular diseases; dihydropyrimidinone; heart rate; cardiac output; force of contraction;

D O I：

10.1016/j.bmcl.2006.06.059

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 4-(substituted)-3,4-dihydropyrimidinone derivatives have been synthesized by heating 1,3 dicarbonyl compounds, urea, and aromatic aldehydes in acetic acid under microwave irradiation conditions. The cardiovascular effects of 3,4-dihydropyrimidinones were studied on isolated perfused frog heart at different dose levels and compared with the activity of digoxin. The interaction of 3,4-dihydropyrimidinones with beta-blocker and calcium channel blocker was also investigated. Compound 4d emerged as the most interesting compound in this series with potential cardiotonic activity. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4893 / 4897

页数：5

共 22 条

[1] DIGITALIS INTOXICATION - PROSPECTIVE CLINICAL STUDY WITH SERUM LEVEL CORRELATIONS [J].