New insights into the structure and function of fatty acid-binding proteins

被引：527

作者：

Zimmerman, AW ^{[1
]}

Veerkamp, JH ^{[1
]}

机构：

[1] Catholic Univ Nijmegen, Ctr Med, Dept Biochem, NL-6500 HB Nijmegen, Netherlands

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2002年 / 59卷 / 07期

关键词：

fatty acid-binding protein; fatty acid transfer; site-directed mutagenesis; gene transcription; cancer; diagnostic marker; signal transduction;

D O I：

10.1007/s00018-002-8490-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fatty acid-binding proteins (FABPs) are members of a superfamily of lipid-binding proteins, and occur intracellularly in vertebrates and invertebrates. This review presents recent findings on the diversity of these FABPs and their proposed roles in fatty acid (FA) metabolism and other cellular processes. Special attention is paid to the structural features of the different mammalian FABP types and the physiological role of these proteins in FA transport, cell growth and differentiation, cellular signalling, gene transcription and cytoprotection. Additionally, data on FABP knockout mice and the implication of FABP in medicine are discussed.

引用

页码：1096 / 1116

页数：21

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