Expression of human β-defensin 2 in human nasal mucosa

被引：23

作者：

Chen, PH ^{[1
]}

Fang, SY ^{[1
]}

机构：

[1] Natl Cheng Kung Univ Hosp, Dept Otolaryngol, Coll Med, Tainan 70428, Taiwan

来源：

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 2004年 / 261卷 / 05期

关键词：

nasal mucosa; defensins; host defense;

D O I：

10.1007/s00405-003-0682-z

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 [耳鼻咽喉科学];

摘要：

Human beta-defensin (HBD)-2, an antimicrobial peptide, has been discovered to be produced by a number of epithelial cells. It is identified as a key element in the innate host defense mechanism. Because little is known about the expression of HBD-2 in the human sinonasal tract, we conducted this study to investigate the expression of the HBD-2 mRNA gene by the reverse transcription polymerase chain reaction (RT-PCR) and localization of HBD-2 peptide by immunohistochemistry in human nasal inferior turbinates and nasal polyps. RT-PCR showed significantly higher expression of HBD-2 mRNA in nasal polyps than in inferior turbinates. Using immunohistochemistry, HBD-2 peptide was predominately localized in surface epithelial cells. Thus, it is feasible that HBD-2 is expressed in nasal mucosa and is upregulated in a condition of chronic inflammation.

引用

页码：238 / 241

页数：4

共 23 条

[1]

Plasma and BAL fluid concentrations of antimicrobial peptides in patients with Mycobacterium avium-intracellulare infection [J].