The functions of the orbitofrontal cortex

被引:910
作者
Rolls, ET [1 ]
机构
[1] Univ Oxford, Dept Expt Psychol, Oxford OX1 3UD, England
关键词
emotion; orbitofrontal cortex; reward reinforcement; taste; olfaction; reversal learning; face expression;
D O I
10.1016/s0278-2626(03)00277-x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The orbitofrontal cortex contains the secondary taste cortex, in which the reward value of taste is represented. It also contains the secondary and tertiary olfactory cortical areas, in which information about the identity and also about the reward value of odours is represented. The orbitofrontal cortex also receives information about the sight of objects from the temporal lobe cortical visual areas, and neurons in it learn and reverse the visual stimulus to which they respond when the association of the visual stimulus with a primary reinforcing stimulus (such as taste) is reversed. This is an example of stimulus-reinforcement association learning, and is a type of stimulus-stimulus association learning. More generally, the stimulus might be a visual or olfactory stimulus, and the primary (unlearned) positive or negative reinforcer a taste or touch. A somatosensory input is revealed by neurons that respond to the texture of food in the mouth, including a population that responds to the mouth feel of fat. In complementary neuroimaging studies in humans, it is being found that areas of the orbitofrontal cortex are activated by pleasant touch, by painful touch, by taste, by smell, and by more abstract reinforcers such as winning or losing money. Damage to the orbitofrontal cortex can impair the learning and reversal of stimulus-reinforcement associations, and thus the correction of behavioural responses when there are no longer appropriate because previous reinforcement contingencies change. The information which reaches the orbitofrontal cortex for these functions includes information about faces, and damage to the orbitofrontal cortex can impair face (and voice) expression identification. This evidence thus shows that the orbitofrontal cortex is involved in decoding and representing some primary reinforcers such as taste and touch; in learning and reversing associations of visual and other stimuli to these primary reinforcers; and in controlling and correcting reward-related and punishment-related behavior, and thus in emotion. The approach described here is aimed at providing a fundamental understanding of how the orbitofrontal cortex actually functions, and thus in how it is involved in motivational behavior such as feeding and drinking, in emotional behavior, and in social behavior. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:11 / 29
页数:19
相关论文
共 146 条
[111]   Responses of neurons in the primate taste cortex to the glutamate ion and to inosine 5'-monophosphate [J].
Rolls, ET ;
Critchley, HD ;
Wakeman, EA ;
Mason, R .
PHYSIOLOGY & BEHAVIOR, 1996, 59 (4-5) :991-1000
[112]   NEUROPHYSIOLOGICAL ANALYSIS OF BRAIN-STIMULATION REWARD IN THE MONKEY [J].
ROLLS, ET ;
BURTON, MJ ;
MORA, F .
BRAIN RESEARCH, 1980, 194 (02) :339-357
[113]   Precis of the brain and emotion [J].
Rolls, ET .
BEHAVIORAL AND BRAIN SCIENCES, 2000, 23 (02) :177-+
[114]   The neurophysiology of backward visual masking:: Information analysis [J].
Rolls, ET ;
Tovée, MJ ;
Panzeri, S .
JOURNAL OF COGNITIVE NEUROSCIENCE, 1999, 11 (03) :300-311
[115]   Different representations of pleasant and unpleasant odours in the human brain [J].
Rolls, ET ;
Kringelbach, ML ;
de Araujo, IET .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 18 (03) :695-703
[116]   PROCESSING SPEED IN THE CEREBRAL-CORTEX AND THE NEUROPHYSIOLOGY OF VISUAL MASKING [J].
ROLLS, ET ;
TOVEE, MJ .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1994, 257 (1348) :9-15
[117]   NEUROPHYSIOLOGICAL MECHANISMS UNDERLYING FACE PROCESSING WITHIN AND BEYOND THE TEMPORAL CORTICAL VISUAL AREAS [J].
ROLLS, ET .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1992, 335 (1273) :11-21
[118]   Functions of the primate temporal lobe cortical visual areas in invariant visual object and face recognition [J].
Rolls, ET .
NEURON, 2000, 27 (02) :205-218
[119]   A THEORY OF EMOTION, AND ITS APPLICATION TO UNDERSTANDING THE NEURAL BASIS OF EMOTION [J].
ROLLS, ET .
COGNITION & EMOTION, 1990, 4 (03) :161-190
[120]  
Rolls ET, 2002, COMPUTATIONAL NEUROS