Erythropoietin and acute renal failure

被引：23

作者：

Sharples, Edward J. ^{[1
]}

Yaqoob, Muhammad M. ^{[1
]}

机构：

[1] Univ London, Queen Mary, William Harvey Res Inst, Ctr Expt Med Nephrol & Crit Care, London EC1M 6BQ, England

来源：

SEMINARS IN NEPHROLOGY | 2006年 / 26卷 / 04期

关键词：

acute renal failure;

D O I：

10.1016/j.semnephrol.2006.05.010

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The hemopoietic growth factor erythropoietin (EPO) has been recognized to be a multifunctional cytokine that plays a key role in ischemic preconditioning in the brain and heart. The EPO receptor is expressed widely in the kidney, and we review the important findings from the use of EPO in experimental models of acute renal failure that show that EPO reduces tubular cell death and hence the dysfunction induced by ischemia reperfusion injury, and we explore how these observations may be translated into the clinical arena. © 2006 Elsevier Inc. All rights reserved.

引用

页码：325 / 331

页数：7

共 62 条

[61] Preconditioning with erythropoietin protects against subsequent ischemia-reperfusion injury in rat kidney [J].