Valproate and valproate-analogues: Potent tools to fight against cancer

被引：87

作者：

Blaheta, RA ^{[1
]}

Nau, H ^{[1
]}

Michaelis, M ^{[1
]}

Cinatl, J ^{[1
]}

机构：

[1] Univ Frankfurt Klinikum, Interdisziplinares Lab Tumor & Virusforsch, Inst Med Virol, Zentrum Hyg, D-6000 Frankfurt, Germany

来源：

CURRENT MEDICINAL CHEMISTRY | 2002年 / 9卷 / 15期

关键词：

valproic acid; propyl-4-yn-valproic acid; heptyl-4-yn-valproic acid; teratogenicity; anti-turnor effects; HDAC; PPAR;

D O I：

10.2174/0929867023369763

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The branched-chain fatty acid valproic acid (VPA) is the most commonly used antiepileptic drug for treating generalized epilepsy. Although originally considered to be of low toxicity, VPA has proved to possess considerable teratogenic potential when applied to the pregnant epileptic women. During the last few years, it has become evident that some of the mechanisms which account for the malformations produced by VPA are related to distinct anti-tumor properties of this compound, This intriguing discovery opens novel aspects for the treatment of tumor patients. In the present review, the biological, biochemical and pharmacological properties of VPA are discussed. Analyses of structure-activity relationships can provide the necessary insight into the molecular structures responsible for the anti-tumor effects.

引用

页码：1417 / 1433

页数：17

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