Fire is a major danger in the large stadium due to fire accompanied with smoke flow and evacuation path. As a part of an effort to improve the life safety in large stadium, the simulation technology combined with fire spread and evacuation had been developed. Besides that, in order to decrease the rate of people death in the large stadium fire, the interface between fire and the evacuation people must be designed according to simulation results, based on the influence laws to human behavior by smoke temperature, CO concentration and extinction coefficient in fire condition. Therefore, the investigation of effect of fire spread on life safety is needed. In this paper, the dynamic changes of walking speed, route choice and mental state is obtained from automatic reading of fire data during the simulation of evacuation. The effect abruptly changes due to time-varying fire smoke parameters, especially local jamming and uneven efficiency of routes. From the simulation, the visual and tried evidences would be provided for safe evacuation in fire emergency in large stadiums.