Severe Dengue, Epidemics in Sri Lanka, 2003-2006

被引：118

作者：

Kanakaratne, Nalaka ^{[1
]}

Wahala, Wahala M. P. B. ^{[2
]}

Messer, William B. ^{[2
]}

Tissera, Hasitha A. ^{[3
]}

Shahani, Aruna ^{[4
]}

Abeysinghe, Nihal ^{[3
]}

de Silva, Aravinda M. ^{[2
]}

Gunasekera, Maya ^{[1
]}

机构：

[1] Genetech Res Inst, Colombo 8, Sri Lanka

[2] Univ N Carolina, Sch Med, Chapel Hill, NC USA

[3] Minist Hlth, Colombo, Sri Lanka

[4] Apollo Hosp, Colombo, Sri Lanka

来源：

EMERGING INFECTIOUS DISEASES | 2009年 / 15卷 / 02期

基金：

美国国家卫生研究院;

关键词：

HEMORRHAGIC-FEVER; MOLECULAR EVOLUTION; OUTBREAK; SELECTION; SPREAD;

D O I：

10.3201/eid1502.080926

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent emergence of dengue hemorrhagic fever in the Indian subcontinent has been well documented in Sri Lanka. We compare recent (2003-2006) and past (1980-1997) dengue surveillance data for Sri Lanka. The 4 dengue virus (DENV) serotypes have been cocirculating in Sri Lanka for > 30 years. Over this period, a new genotype of DENV-1 has replaced an old genotype. Moreover, new clades of DENV-3 genotype III viruses have replaced older clades. Emergence of new clades of DENV-3 in 1989 and 2000 coincided with abrupt increases in the number of reported dengue cases, implicating this serotype in severe epidemics. In 19801997, most reported dengue cases were in children. Recent epidemics have been characterized by many cases in children and adults. Changes in local transmission dynamics and genetic changes in DENV-3 are likely increasing emergence of severe dengue epidemics in Sri Lanka.

引用

页码：192 / 199

页数：8

共 26 条

[1] Molecular evolution of dengue 2 virus in Puerto Rico: positive selection in the viral envelope accompanies clade reintroduction [J].