The molecular mechanics of eukaryotic translation

被引：385

作者：

Kapp, LD ^{[1
]}

Lorsch, JR ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Biophys & Biophys Chem, Sch Med, Baltimore, MD 21205 USA

来源：

ANNUAL REVIEW OF BIOCHEMISTRY | 2004年 / 73卷

关键词：

protein synthesis; initiation; elongation; termination; recycling;

D O I：

10.1146/annurev.biochem.73.030403.080419

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Great advances have been made in the past three decades in understanding the molecular mechanics underlying protein synthesis in bacteria, but our understanding of the corresponding events in eukaryotic organisms is only beginning to catch up. In this review we describe the current state of our knowledge and ignorance of the molecular mechanics underlying eukaryotic translation. We discuss the mechanisms conserved across the three kingdoms of life as well as the important divergences that have taken place in the pathway.

引用

页码：657 / 704

页数：48

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