Antigens with application toward immune control of blood-feeding parasitic nematodes

被引：10

作者：

Jasmer, DP

McGuire, TC

机构：

[1] Department of Veterinary Microbiology and Pathology, Washington Slate University, Pullman

来源：

BRITISH VETERINARY JOURNAL | 1996年 / 152卷 / 03期

关键词：

GA1; gut antigen; Haemonchus contortus; H11; haematophages; immunity; microvilli; monoclonal antibody; mucosa; nematode;

D O I：

10.1016/S0007-1935(96)80099-6

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

This review considers progress toward immune control of nematode parasites that feed on mammalian host blood. Approaches to identify relevant parasite antigens include use of irradiated larvae, somatic antigens, metabolites, enzymes and gut antigens. Because significant immune protection has more recently been achieved using gut antigens of the blood-feeding parasite Haemonchus contortus, these antigens are considered in greater detail. Issues discussed are implications of gut antigens in immune control, potential mechanisms involved in this immunity, biochemical characteristics of gut antigens and potential application of gut antigens to immune control of other blood-feeding nematodes.

引用

页码：251 / 268

页数：18

共 92 条

[41] STUDIES ON RESISTANCE IN CALVES TO EXPERIMENTAL INFECTION WITH NODULAR WORM OESOPHAGOSTOMUM RADIATUM (RUDOLPHI 1803) .3. STIMULATION OF RESISTANCE BY MULTIPLE INFECTIONS WITH LARVAL STAGES [J].