Easy Route to Functionalize Iron Oxide Nanoparticles via Long-Term Stable Thiol Groups

被引：42

作者：

Maurizi, L. ^{[1
]}

Bisht, H. ^{[1
]}

Bouyer, F. ^{[1
]}

Millot, N. ^{[1
]}

机构：

[1] Univ Bourgogne, CNRS, Inst Carnot Bourgogne, UMR 5209, F-21078 Dijon, France

来源：

LANGMUIR | 2009年 / 25卷 / 16期

关键词：

CONTRAST AGENTS; MAGHEMITE NANOPARTICLES; IN-VITRO; PROTEIN; CELLS; NANOCRYSTALS; HYPERTHERMIA; FERROFLUIDS; RELAXATION; CANCER;

D O I：

10.1021/la901602w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The functionalization of superparamagnetic iron oxide nanoparticles (SPIOs) by meso-2,3-dimercaptosuccinic acid (DMSA) was investigated. Under ambient conditions, the thiol groups from DMSA are not stable and do not allow a direct functionalization without storage in stringent conditions or a chemical regeneration of free thiols. In this study, we have developed a protocol based on poly(ethylene glycol) (PEG) grafting of SPIO prior to DMSA anchoring. We have observed that PEG helps to increase the stability of thiol groups tinder ambient conditions. The thiol functionalized SPIOs were stable under physiological pH and ionic strength as determined by Ellman's essay and allowed us to graft a thiol reactive fluorescent dye: tetramethylrhodamine-5-maleimide (TMRM).

引用

页码：8857 / 8859

页数：3

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