Triterpenoids from Tripterygium wilfordii

被引：54

作者：

Duan, HQ

Takaishi, Y

Momota, H

Ohmoto, Y

Taki, T

Jia, YF

Li, D

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan

[2] Otsuka Pharmaceut Co Ltd, Cellular Technol Inst, Tokushima 77101, Japan

[3] Shanghai Med Univ, Sch Pharm, Shanghai 200032, Peoples R China

来源：

PHYTOCHEMISTRY | 2000年 / 53卷 / 07期

关键词：

Tripterygium wilfordii; triterpenoids; immunosuppressive activity;

D O I：

10.1016/S0031-9422(00)00007-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The extract (T-II) of Tripterygium wilfordii Hook f. afforded four triterpenoids: wilforic acid D (3 beta,24-epoxy-2 alpha-hydroxy-24R*- ethoxy-29-friedelanoic acid); (E) 3 beta,24-epoxy-2-oxo-3 alpha-hydroxy-29-friedelanoic acid; (F) 2 beta-hydroxy-3-oxo-friedelan-29-oic acid; 29-hydroxy-3-oxo-olean-12-en-28-oic acid and 17 known triterpenoids. Their structures were established on the basis of spectroscopic studies. In a bioactivity analysis, only the known dulcioic acid compound showed a significant inhibitory effect on cytokine production. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：805 / 810

页数：6

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