Antiangiogenic activity of synthetic dihydrobenzofuran lignans

被引：88

作者：

Apers, S

Paper, D

Bürgermeister, J

Baronikova, S

Van Dyck, S

Lemière, G

Vlietinck, A

Pieters, L

机构：

[1] Univ Instelling Antwerp, Dept Pharmaceut Sci, B-2610 Wilrijk, Belgium

[2] Univ Regensburg, Dept Pharm, D-93040 Regensburg, Germany

[3] Univ Antwerp, Dept Chem, B-2020 Antwerp, Belgium

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 05期

关键词：

D O I：

10.1021/np0103968

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A series of synthetic dihydrobenzofuran lignans, obtained by biomimetic oxidative dimerization of caffeic or ferulic acid methyl ester followed by derivatization reactions, was tested for its antiangiogenic activity in the CAM (chorioallantoic membrane) assay. The dimerization product of caffeic acid methyl ester (2a) (methyl (E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-3-methoxycarbonyl-2,3-dihydro-1-bunzofuran-5-yl]prop-2-enoate) showed a pronounced antiangiogenic activity, especially the 2R,3R-enantiomer.

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收藏

页码：718 / 720

页数：3

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