TGF-β Superfamily Signaling in Embryonic Development and Homeostasis

被引：616

作者：

Wu, Mary Y. ^{[1
]}

Hill, Caroline S. ^{[1
]}

机构：

[1] Canc Res UK London Res Inst, Lab Dev Signalling, London WC2A 3PX, England

来源：

DEVELOPMENTAL CELL | 2009年 / 16卷 / 03期

关键词：

LEFT-RIGHT ASYMMETRY; DECAPENTAPLEGIC MORPHOGEN GRADIENT; EPITHELIAL-MESENCHYMAL TRANSITION; BRACHYDACTYLY TYPE A2; DROSOPHILA EMBRYO; XENOPUS EMBRYOS; SMAD1/5; PHOSPHORYLATION; VERTEBRATE DEVELOPMENT; TRANSCRIPTION FACTORS; ANTEROPOSTERIOR AXIS;

D O I：

10.1016/j.devcel.2009.02.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

TGF-beta superfamily signaling pathways emerged with the evolution of multicellular animals, suggesting that these pathways contribute to the increased diversity and complexity required for the development and homeostasis of these organisms. In this review we begin by exploring some key developmental and disease processes requiring TGF-beta ligands to underscore the fundamental importance of these pathways before delving into the molecular mechanism of signal transduction, focusing on recent findings. Finally, we discuss how these ligands act as morphogens, how their activity and signaling range is regulated, and how they interact with other signaling pathways to achieve their specific and varied functional roles.

引用

页码：329 / 343

页数：15

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