Microbeam developments and applications: A low linear energy transfer perspective

被引：27

作者：

Resat, MS

Morgan, WF

机构：

[1] Pacific NW Natl Lab, Richland, WA 99352 USA

[2] Univ Maryland, Radiat Oncol Res Lab, Baltimore, MD 21201 USA

[3] Univ Maryland, Greenebaum Canc Ctr, Baltimore, MD 21201 USA

来源：

CANCER AND METASTASIS REVIEWS | 2004年 / 23卷 / 3-4期

关键词：

microbeam; low-LET; radiation induced bystander effect; non-targeted effects of ionizing radiation;

D O I：

10.1023/B:CANC.0000031770.96320.1e

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the last few years there has been a significant increase in the number of centers having, or developing, both high- and low-linear energy transfer (LET) microbeams for radiobiological investigations. In this review, we will discuss the various approaches for developing low-LET single cell irradiation devices and consider the instrument designs and how the machines capabilities can be exploited to investigate targeted and non-targeted effects of low-LET irradiation.

引用

页码：323 / 331

页数：9

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