Interleukin-6 in aging and chronic disease: A magnificent pathway

被引：505

作者：

Maggio, Marcello

Guralnik, Jack M.

Longo, Dan L.

Ferrucci, Luigi

机构：

[1] NIA, Clin Res Branch, Longitudinal Studies Sect, NIH, Baltimore, MD USA

[2] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2006年 / 61卷 / 06期

关键词：

D O I：

10.1093/gerona/61.6.575

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The human interleukin IL-6 was originally cloned in 1986. In 1993, William Ershler, in his article "IL-6: A Cytokine for Gerontologists," indicated IL-6 as one of the main signaling pathways modulating the complex relationship between aging and chronic morbidity. Over the last 12 years, our understanding of the role of IL-6 in human physiology and pathology has substantially grown, although some of the questions originally posed by Ershler are still debated. In this review, we will focus on IL-6 structure, IL-6 signaling, and trans signaling pathways, and the role of IL-6 in geriatric syndromes and chronic disease. In the final section of this review, we dissect the critical elements of the IL-6 signaling pathway and point out targets for intervention that are targeted by emerging drugs, some still on the horizon and others already being tested in clinical trials.

引用

页码：575 / 584

页数：10

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