CCCTC-binding factor: to loop or to bridge

被引：41

作者：

Zlatanova, J. ^{[1
]}

Caiafa, P. ^{[2
,3
]}

机构：

[1] Univ Wyoming, Dept Mol Biol, Laramie, WY 82071 USA

[2] Univ Roma La Sapienza, Fac Med & Surg 2, Dept Cellular Biotechnol & Hematol, Rome, Italy

[3] Fdn Cenci Bolognetti, Inst Pasteur, Rome, Italy

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2009年 / 66卷 / 10期

关键词：

Genome organization; transcription; imprinting; boundary elements; X-chromosome inactivation; intra- and inter-chromosomal interactions; X-CHROMOSOME INACTIVATION; IMPRINTING CONTROL REGION; INSULATOR PROTEIN CTCF; MAJOR HISTOCOMPATIBILITY COMPLEX; ENHANCER-BLOCKING ACTIVITY; METHYLATION-FREE DOMAINS; RNA-POLYMERASE-II; BETA-GLOBIN LOCUS; HUMAN GENOME; GENE-REGULATION;

D O I：

10.1007/s00018-009-8647-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eukaryotic genomes have complex spatial organization in the nucleus. The factors and the mechanisms involved in this organization remain an enigma. Among the many proteins implicated in such a role, the ubiquitous Zn-finger protein CTCF stands out. Here we summarize the evidence placing CTCF in the enviable position of a master organizer of the genome. CTCF can form loops in cis, and can bridge sequences located on different chromosomes in trans. The thousands of CTCF binding sites, identified in recent genome-wide localization studies, and their distribution along the genome further support a crucial role of CTCF as a chromatin organizer.

引用

页码：1647 / 1660

页数：14

共 76 条

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