Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection

被引:301
作者
Favre, David [1 ]
Lederer, Sharon [2 ]
Kanwar, Bittoo [1 ,3 ]
Ma, Zhong-Min [4 ]
Proll, Sean [2 ]
Kasakow, Zeljka [1 ]
Mold, Jeff [1 ]
Swainson, Louise [1 ]
Barbour, Jason D. [5 ]
Baskin, Carole R. [2 ,6 ]
Palermo, Robert [2 ]
Pandrea, Ivona [7 ]
Miller, Christopher J. [4 ]
Katze, Michael G. [2 ,6 ]
McCune, Joseph M. [1 ]
机构
[1] Univ Calif San Francisco, Div Expt Med, Dept Med, San Francisco, CA 94143 USA
[2] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA
[3] Univ Calif San Francisco, Div Gastroenterol Hepatol & Nutr, Dept Pediat, San Francisco, CA 94143 USA
[4] Univ Calif Davis, Calif Natl Primate Res Ctr, Ctr Comparat Med, Davis, CA USA
[5] Univ Calif San Francisco, Div HIV AIDS, Dept Med, San Francisco, CA 94143 USA
[6] Univ Washington, Washington Natl Primate Res Ctr, Seattle, WA 98195 USA
[7] Tulane Natl Primate Res Ctr, Covington, LA USA
关键词
SIMIAN IMMUNODEFICIENCY VIRUS; AFRICAN-GREEN MONKEYS; GROWTH-FACTOR-BETA; IMMUNE ACTIVATION; VIRAL REPLICATION; SOOTY MANGABEYS; HIV-INFECTION; CD4(+); DEPLETION; RESPONSES;
D O I
10.1371/journal.ppat.1000295
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Chronic immune activation and progression to AIDS are observed after SIV infection in macaques but not in natural host primate species. To better understand this dichotomy, we compared acute pathogenic SIV infection in pigtailed macaques (PTs) to non-pathogenic infection in African green monkeys (AGMs). SIVagm-infected PTs, but not SIVagm-infected AGMs, rapidly developed systemic immune activation, marked and selective depletion of IL-17-secreting (Th17) cells, and loss of the balance between Th17 and T regulatory (Treg) cells in blood, lymphoid organs, and mucosal tissue. The loss of Th17 cells was found to be predictive of systemic and sustained T cell activation. Collectively, these data indicate that loss of the Th17 to Treg balance is related to SIV disease progression.
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页数:17
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