Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection

被引：304

作者：

Favre, David ^{[1
]}

Lederer, Sharon ^{[2
]}

Kanwar, Bittoo ^{[1
,3
]}

Ma, Zhong-Min ^{[4
]}

Proll, Sean ^{[2
]}

Kasakow, Zeljka ^{[1
]}

Mold, Jeff ^{[1
]}

Swainson, Louise ^{[1
]}

Barbour, Jason D. ^{[5
]}

Baskin, Carole R. ^{[2
,6
]}

Palermo, Robert ^{[2
]}

Pandrea, Ivona ^{[7
]}

Miller, Christopher J. ^{[4
]}

Katze, Michael G. ^{[2
,6
]}

McCune, Joseph M. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Div Expt Med, Dept Med, San Francisco, CA 94143 USA

[2] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

[3] Univ Calif San Francisco, Div Gastroenterol Hepatol & Nutr, Dept Pediat, San Francisco, CA 94143 USA

[4] Univ Calif Davis, Calif Natl Primate Res Ctr, Ctr Comparat Med, Davis, CA USA

[5] Univ Calif San Francisco, Div HIV AIDS, Dept Med, San Francisco, CA 94143 USA

[6] Univ Washington, Washington Natl Primate Res Ctr, Seattle, WA 98195 USA

[7] Tulane Natl Primate Res Ctr, Covington, LA USA

来源：

PLOS PATHOGENS | 2009年 / 5卷 / 02期

关键词：

SIMIAN IMMUNODEFICIENCY VIRUS; AFRICAN-GREEN MONKEYS; GROWTH-FACTOR-BETA; IMMUNE ACTIVATION; VIRAL REPLICATION; SOOTY MANGABEYS; HIV-INFECTION; CD4(+); DEPLETION; RESPONSES;

D O I：

10.1371/journal.ppat.1000295

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Chronic immune activation and progression to AIDS are observed after SIV infection in macaques but not in natural host primate species. To better understand this dichotomy, we compared acute pathogenic SIV infection in pigtailed macaques (PTs) to non-pathogenic infection in African green monkeys (AGMs). SIVagm-infected PTs, but not SIVagm-infected AGMs, rapidly developed systemic immune activation, marked and selective depletion of IL-17-secreting (Th17) cells, and loss of the balance between Th17 and T regulatory (Treg) cells in blood, lymphoid organs, and mucosal tissue. The loss of Th17 cells was found to be predictive of systemic and sustained T cell activation. Collectively, these data indicate that loss of the Th17 to Treg balance is related to SIV disease progression.

引用

页数：17

共 70 条

[1] Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens [J].

Aandahl, EM ;

Michaëlsson, J ;

Moretto, WJ ;

Hecht, FA ;

Nixon, DF .

JOURNAL OF VIROLOGY, 2004, 78 (05) :2454-2459

[2] Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells [J].

Acosta-Rodriguez, Eva V. ;

Napolitani, Giorgio ;

Lanzavecchia, Antonio ;

Sallusto, Federica .

NATURE IMMUNOLOGY, 2007, 8 (09) :942-949

[3] Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells [J].

Acosta-Rodriguez, Eva V. ;

Rivino, Laura ;

Geginat, Jens ;

Jarrossay, David ;

Gattorno, Marco ;

Lanzavecchia, Antonio ;

Sallusto, Federica ;

Napolitani, Giorgio .

NATURE IMMUNOLOGY, 2007, 8 (06) :639-646

[4] CROSS-LINKING CD4 BY HUMAN IMMUNODEFICIENCY VIRUS-GP120 PRIMES T-CELLS FOR ACTIVATION-INDUCED APOPTOSIS [J].

BANDA, NK ;

BERNIER, J ;

KURAHARA, DK ;

KURRLE, R ;

HAIGWOOD, N ;

SEKALY, RP ;

FINKEL, TH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (04) :1099-1106

[5] Simian immunodeficiency virus of African green monkeys is apathogenic in the newborn natural host [J].

Beer, B ;

Denner, J ;

Brown, CR ;

Norley, S ;

zur Megede, J ;

Coulibaly, C ;

Plesker, R ;

Holzammer, S ;

Baier, M ;

Hirsch, VM ;

Kurth, R .

JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1998, 18 (03) :210-220

[6] Natural regulatory T cells in infectious disease [J].

Belkaid, Y ;

Rouse, BT .

NATURE IMMUNOLOGY, 2005, 6 (04) :353-360

[7] Regulatory T cells and infection: a dangerous necessity [J].

Belkaid, Yasmine .

NATURE REVIEWS IMMUNOLOGY, 2007, 7 (11) :875-888

[8]

Betti M, 2006, ANN ONCOL, V17, P235

[9] Natural versus adaptive regulatory T cells [J].

Bluestone, JA ;

Abbas, AK .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (03) :253-257

[10] HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells [J].

Boasso, Adriano ;

Herbeuval, Jean-Philippe ;

Hardy, Andrew W. ;

Anderson, Stephanie A. ;

Dolan, Matthew J. ;

Fuchs, Dietmar ;

Shearer, Gene M. .

BLOOD, 2007, 109 (08) :3351-3359

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