Molecularly imprinted polymers as affinity-based separation media for sample preparation

被引：146

作者：

Haginaka, Jun ^{[1
]}

机构：

[1] Mukogawa Womens Univ, Fac Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan

来源：

JOURNAL OF SEPARATION SCIENCE | 2009年 / 32卷 / 10期

关键词：

Affinity-based media; Bioanalysis; Environmental analysis; Molecularly imprinted polymer; Molecularly imprinted solid-phase extraction; SOLID-PHASE EXTRACTION; PERFORMANCE LIQUID-CHROMATOGRAPHY; FLOW-INJECTION CHEMILUMINESCENCE; SELECTIVE ONLINE EXTRACTION; TANDEM MASS-SPECTROMETRY; GROWTH-FACTOR RECEPTOR; RIVER WATER SAMPLES; BISPHENOL-A; PRECIPITATION POLYMERIZATION; URINE SAMPLES;

D O I：

10.1002/jssc.200900085

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This review article deals with molecularly imprinted polymers (MIPs) as affinity-based separation media for sample preparation. An over view of two types of MIPs (molecularly imprinted particle and monolith) used for the sample preparation and modes of molecularly imprinted SPE (online mode, offline mode, on-column extraction, SPME, and microextraction in packed syringe) is given, focusing on the advantages and disadvantages of these types and modes. Next, problems (template leakage and incompatibility with aqueous conditions) associated with molecularly imprinted SPE and how to overcome those problems are described. Finally, pharmaceutical, food, bioanalytical, and environmental application of molecularly imprinted SPE will be discussed.

引用

页码：1548 / 1565

页数：18

共 201 条

[1] Microextraction in packed syringe online with liquid chromatography-tandem mass spectrometry: Molecularly imprinted polymer as packing material for MEPS in selective extraction of ropivacaine from plasma [J].