Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia

被引：327

作者：

Sabir, Jamal S. M. ^{[1
]}

Lam, Tommy T. -Y. ^{[2
,3
,4
,5
]}

Ahmed, Mohamed M. M. ^{[1
,8
]}

Li, Lifeng ^{[3
,4
,5
]}

Shen, Yongyi ^{[3
,4
,5
]}

Abo-Aba, Salah E. M. ^{[1
,9
]}

Qureshi, Muhammad I. ^{[1
]}

Abu-Zeid, Mohamed ^{[1
,9
]}

Zhang, Yu ^{[2
,3
,4
,5
]}

Khiyami, Mohammad A. ^{[10
]}

Alharbi, Njud S. ^{[1
]}

Hajrah, Nahid H. ^{[1
]}

Sabir, Meshaal J. ^{[1
]}

Mutwakil, Mohammed H. Z. ^{[1
]}

Kabli, Saleh A. ^{[1
]}

Alsulaimany, Faten A. S. ^{[1
]}

Obaid, Abdullah Y. ^{[11
]}

Zhou, Boping ^{[2
]}

Smith, David K. ^{[4
,5
]}

Holmes, Edward C. ^{[6
,7
]}

Zhu, Huachen ^{[2
,3
,4
,5
]}

Guan, Yi ^{[1
,2
,3
,4
,5
]}

机构：

[1] King Abdulaziz Univ, Fac Sci, Dept Biol Sci, Biotechnol Res Grp, Jeddah 21589, Saudi Arabia

[2] Univ Hong Kong, Shenzhen Peoples Hosp 3, State Key Lab Emerging Infect Dis, Shenzhen Branch, Shenzhen, Peoples R China

[3] Shantou Univ, Univ Hong Kong, Joint Inst Virol, Shantou, Peoples R China

[4] Univ Hong Kong, Sch Publ Hlth, Ctr Influenza Res, Hong Kong, Hong Kong, Peoples R China

[5] Univ Hong Kong, Sch Publ Hlth, State Key Lab Emerging Infect Dis, Hong Kong, Hong Kong, Peoples R China

[6] Univ Sydney, Marie Bashir Inst Infect Dis & Biosecur, Charles Perkins Ctr, Sch Biol Sci, Sydney, NSW 2006, Australia

[7] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia

[8] City Sci Res & Technol Applicat, Genet Engn & Biotechnol Res Inst, Dept Nucle Acids Res, Alexandria, Egypt

[9] Natl Res Ctr, Genet Engn & Biotechnol Div, Microbial Genet Dept, Giza, Egypt

[10] King Abdulaziz City Sci & Technol, Riyadh 11442, Saudi Arabia

[11] King Abdulaziz Univ, Fac Sci, Dept Chem, Jeddah 21589, Saudi Arabia

来源：

SCIENCE | 2016年 / 351卷 / 6268期

基金：

英国医学研究理事会;

关键词：

RESPIRATORY SYNDROME CORONAVIRUS; MIDDLE-EAST; DROMEDARY CAMELS; ANTIBODIES; IDENTIFICATION; LIVESTOCK; TRACT;

D O I：

10.1126/science.aac8608

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Outbreaks of Middle East respiratory syndrome (MERS) raise questions about the prevalence and evolution of the MERS coronavirus (CoV) in its animal reservoir. Our surveillance in Saudi Arabia in 2014 and 2015 showed that viruses of the MERS-CoV species and a human CoV 229E-related lineage co-circulated at high prevalence, with frequent co-infections in the upper respiratory tract of dromedary camels. Including a betacoronavirus 1 species, we found that dromedary camels share three CoV species with humans. Several MERS-CoV lineages were present in camels, including a recombinant lineage that has been dominant since December 2014 and that subsequently led to the human outbreaks in 2015. Camels therefore serve as an important reservoir for the maintenance and diversification of the MERS-CoVs and are the source of human infections with this virus.

引用

页码：81 / 84

页数：4

共 23 条

[1] Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels [J].

Adney, Danielle R. ;

van Doremalen, Neeltje ;

Brown, Vienna R. ;

Bushmaker, Trenton ;

Scott, Dana ;

de Wit, Emmie ;

Bowen, Richard A. ;

Munster, Vincent J. .

EMERGING INFECTIOUS DISEASES, 2014, 20 (12) :1999-2005

[2]

Alagaili AN, 2014, MBIO, V5, DOI [10.1128/mBio.00884-14, 10.1128/mBio.01482-14]

[3] Evidence for Camel-to-Human Transmission of MERS Coronavirus [J].

Azhar, Esam I. ;

El-Kafrawy, Sherif A. ;

Farraj, Suha A. ;

Hassan, Ahmed M. ;

Al-Saeed, Muneera S. ;

Hashem, Anwar M. ;

Madani, Tariq A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (26) :2499-2505

[4]

Bermingham A, 2012, EUROSURVEILLANCE, V17, P6

[5] Antibodies against MERS Coronavirus in Dromedary Camels, Kenya, 1992-2013 [J].

Corman, Victor M. ;

Jores, Joerg ;

Meyer, Benjamin ;

Younan, Mario ;

Liljander, Anne ;

Said, Mohammed Y. ;

Gluecks, Ilona ;

Lattwein, Erik ;

Bosch, Berend-Jan ;

Drexler, Jan Felix ;

Bornstein, Set ;

Drosten, Christian ;

Mueller, Marcel A. .

EMERGING INFECTIOUS DISEASES, 2014, 20 (08) :1319-1322

[6] Rooting the Phylogenetic Tree of Middle East Respiratory Syndrome Coronavirus by Characterization of a Conspecific Virus from an African Bat [J].

Corman, Victor Max ;

Ithete, Ndapewa Laudika ;

Richards, Leigh Rosanne ;

Schoeman, M. Corrie ;

Preiser, Wolfgang ;

Drosten, Christian ;

Drexler, Jan Felix .

JOURNAL OF VIROLOGY, 2014, 88 (19) :11297-11303

[7] Identification and Characterization of a Novel Alpaca Respiratory Coronavirus Most Closely Related to the Human Coronavirus 229E [J].

Crossley, Beate M. ;

Mock, Richard E. ;

Callison, Scott A. ;

Hietala, Sharon K. .

VIRUSES-BASEL, 2012, 4 (12) :3689-3700

[8] Identification of a novel coronavirus possibly associated with acute respiratory syndrome in alpacas (Vicugna pacos) in California, 2007 [J].

Crossley, Beate M. ;

Barr, Bradd C. ;

Magdesian, K. Gary ;

Ing, Michelle ;

Mora, Daniel ;

Jensen, David ;

Loretti, Alexandre P. ;

McConnell, Ty ;

Mock, Richard .

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 2010, 22 (01) :94-97

[9] Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group [J].

de Groot, Raoul J. ;

Baker, Susan C. ;

Baric, Ralph S. ;

Brown, Caroline S. ;

Drosten, Christian ;

Enjuanes, Luis ;

Fouchier, Ron A. M. ;

Galiano, Monica ;

Gorbalenya, Alexander E. ;

Memish, Ziad A. ;

Perlman, Stanley ;

Poon, Leo L. M. ;

Snijder, Eric J. ;

Stephens, Gwen M. ;

Woo, Patrick C. Y. ;

Zaki, Ali M. ;

Zambon, Maria ;

Ziebuhr, John .

JOURNAL OF VIROLOGY, 2013, 87 (14) :7790-7792

[10]

Farag Elmoubasher A. B. A., 2015, Infection Ecology & Epidemiology, V5, P28305, DOI 10.3402/iee.v5.28305

← 1 2 3 →