Nodule management protocol of the NELSON randomised lung cancer screening trial

被引:326
作者
Xu, Dong Ming
Gietema, Hester
de Koning, Harry
Vernhout, Rene
Nackaerts, Kristiaan
Prokop, Mathias
Weenink, Carla
Lammers, Jan-Willem
Groen, Harry
Oudkerk, Matthijs
van Klaveren, Rob
机构
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Radiol, NL-9700 RB Groningen, Netherlands
[2] Univ Med Ctr Utrecht, Dept Radiol, NL-3508 GA Utrecht, Netherlands
[3] Erasmus Med Ctr Rotterdam, Dept Publ Hlth, NL-3015 GD Rotterdam, Netherlands
[4] Erasmus Med Ctr Rotterdam, Dept Pulmonol, NL-3015 GD Rotterdam, Netherlands
[5] Univ Hosp Gasthuisberg, Dept Pulmonol, B-3000 Louvain, Belgium
[6] Kennemer Gasthuis, Dept Pulmonol, NL-2000 AK Haarlem, Netherlands
[7] Univ Med Ctr Utrecht, Dept Pulmonol, NL-3508 GA Utrecht, Netherlands
[8] Univ Groningen, Univ Med Ctr Groningen, Dept Pulmonol, NL-9700 RB Groningen, Netherlands
关键词
lung cancer; screening; multi-slice CT; nodules; management; growth;
D O I
10.1016/j.lungcan.2006.08.006
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
In December 2003, the Dutch-Belgian NELSON trial, a Dutch acronym for "Nederlands-Leuvens Longkanker Screenings ONderzoek", has been launched. Primary objective of the NELSON trial is to investigate whether screening for lung cancer by 16-detector multi-slice CT with 16 mm x 0.75 mm collimation and 15 mm table feed per rotation (pitch = 1.5) in year 1, 2 and 4 wilt lead to a decrease in lung cancer mortality in high risk subjects of at least 25% compared to a control group which receives no screening. In this paper, the screening regimen and the classification and management of the screen-detected nodules at baseline and incidence screening is presented. This is the first large lung cancer screening trial in which the nodule management protocol is based on volumetric nodule assessment and the presence or absence of growth. Furthermore, the quality assurance measures and the NELSON management system (NMS) are presented. (C) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:177 / 184
页数:8
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