Function of BMPs and BMP antagonists in adult bone

被引：48

作者：

Abe, Etsuko

机构：

[1] CUNY Mt Sinai Sch Med, Dept Med, Div Endocrinol, Mt Sinai Bone Program, New York, NY 10029 USA

[2] Bronx VA Med Ctr, Bronx, NY 10468 USA

来源：

SKELETAL DEVELOPMENT AND REMODELING IN HEALTH, DISEASE, AND AGING | 2006年 / 1068卷

关键词：

BMP; BMP antagonist; Wnt; catenin; osteoblast; bone remodeling;

D O I：

10.1196/annals.1346.007

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The expression and function of BMPs and BMPs in bone tissues have been studied for a long time because of their remarkable activities. However, their biological functions in normal bone-remodeling in adults were not fully understood until recently. Advanced technologies using gene manipulation were used to study their roles in adulthood. In addition, findings of new BMP antagonists and the effect of Wnt-canonical pathways on bone features also provided new insights in bone studies.

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页码：41 / 53

页数：13

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