Cholinergic control of heart rate by nitric oxide is site specific

被引：51

作者：

Herring, N ^{[1
]}

Danson, EJF ^{[1
]}

Paterson, DJ ^{[1
]}

机构：

[1] Univ Oxford, Physiol Lab, Oxford OX1 3PT, England

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2002年 / 17卷

关键词：

D O I：

10.1152/nips.01386.2002

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Parasympathetic control of heart rate involves the exocytotic release of acetylcholine and muscarinic receptor regulation of pacemaking currents. Endogenous nitric oxide can potentially regulate all of these processes; however, recent work suggests that the main functional role of nitric oxide lies in the modulation of acetylcholine release.

引用

收藏

页码：202 / 206

页数：5

相关论文

共 20 条

[11] NO-cGMP pathway increases the hyperpolarisation-activated current, If, and heart rate during adrenergic stimulation [J].

Herring, N ;

Rigg, L ;

Terrar, DA ;

Paterson, DJ .

CARDIOVASCULAR RESEARCH, 2001, 52 (03) :446-453

[12] Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro [J].

Herring, N ;

Paterson, DJ .

JOURNAL OF PHYSIOLOGY-LONDON, 2001, 535 (02) :507-518

[13] Regulation of the L-type Ca2+ channel during cardiomyogenesis:: switch from NO to adenylyl cyclase-mediated inhibition [J].

Ji, GJ ;

Fleischmann, BK ;

Bloch, W ;

Feelisch, M ;

Andressen, C ;

Addicks, K ;

Hescheler, J .

FASEB JOURNAL, 1999, 13 (02) :313-324

[14] Interaction between neuronal nitric oxide synthase and inhibitory G protein activity in heart rate regulation in conscious mice [J].

Jumrussirikul, P ;

Dinerman, J ;

Dawson, TM ;

Dawson, VL ;

Ekelund, U ;

Georgakopoulos, D ;

Schramm, LP ;

Calkins, H ;

Snyder, SH ;

Hare, JM ;

Berger, RD .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (07) :1279-1285

[15] Nitric oxide can increase heart rate by stimulating the hyperpolarization-activated inward current, I-f [J].

Musialek, P ;

Lei, M ;

Brown, HF ;

Paterson, DJ ;

Casadei, B .

CIRCULATION RESEARCH, 1997, 81 (01) :60-68

[16] Adenoviral vector demonstrates that angiotensin II-induced depression of the cardiac baroreflex is mediated by endothelial nitric oxide synthase in the nucleus tractus solitarii of the rat [J].

Paton, JFR ;

Deuchars, J ;

Ahmad, Z ;

Wong, LF ;

Murphy, D ;

Kasparov, S .

JOURNAL OF PHYSIOLOGY-LONDON, 2001, 531 (02) :445-458

[17] Inhibition of nitric oxide synthase slows heart rate recovery from cholinergic activation [J].

Sears, CE ;

Choate, JK ;

Paterson, DJ .

JOURNAL OF APPLIED PHYSIOLOGY, 1998, 84 (05) :1596-1603

[18] NO-cGMP pathway accentuates the decrease in heart rate caused by cardiac vagal nerve stimulation [J].

Sears, CE ;

Choate, JK ;

Paterson, DJ .

JOURNAL OF APPLIED PHYSIOLOGY, 1999, 86 (02) :510-516

[19] Role of the NO-cGMP pathway in the muscarinic regulation of the L-type Ca2+ current in human atrial myocytes [J].

Vandecasteele, G ;

Eschenhagen, T ;

Fischmeister, R .

JOURNAL OF PHYSIOLOGY-LONDON, 1998, 506 (03) :653-663

[20] Muscarinic and β-adrenergic regulation of heart rate, force of contraction and calcium current is preserved in mice lacking endothelial nitric oxide synthase [J].

Vandecasteele, G ;

Eschenhagen, T ;

Scholz, H ;

Stein, B ;

Verde, I ;

Fischmeister, R .

NATURE MEDICINE, 1999, 5 (03) :331-334