Treatment of newly diagnosed pediatric epilepsy -: A community-based study

被引:21
作者
Berg, AT [1 ]
Levy, SR
Testa, FM
Shinnar, S
机构
[1] No Illinois Univ, Dept Biol Sci, De Kalb, IL 60115 USA
[2] Yale Univ, Dept Pediat, New Haven, CT 06520 USA
[3] Yale Univ, Dept Neurol, New Haven, CT 06520 USA
[4] Albert Einstein Coll Med, Montefiore Med Ctr, Dept Neurol, Bronx, NY 10467 USA
[5] Albert Einstein Coll Med, Montefiore Med Ctr, Dept Pediat, Bronx, NY 10467 USA
来源
ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE | 1999年 / 153卷 / 12期
关键词
D O I
10.1001/archpedi.153.12.1267
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective: To determine the patterns and frequency of treatment and use of specific drugs for newly diagnosed pediatric epilepsy. Design and Setting: Prospective, community-based study. Children were recruited from physicians in Connecticut from 1993 to 1997. Patients: Children aged 1 month through 15 years at the time of their first seizure, who had 2 or more unprovoked seizures, and who were newly diangosed during the: recruitment period were eligible. Main Outcome Measure: Initiation of treatment at diagnosis and within 1 year after diagnosis of epilepsy. Results: Of 613 children, 482 (78.6%) were treated at the time of initial diagnosis. By 6 months another 10.3% were treated, and by 12 months 90% of the cohort had been treated. The most commonly prescribed antiepileptic drug (AED) nas carbamazepine (38.8%) followed by sodium valproate (18.4%). Only 1 child received an investigational drug and none received any of the most recently approved drugs as a first AED. Children with idiopathic and secondarily generalized forms of epilepsy were most likely to be treated (90%-100%), whereas children with idiopathic localization-related epilepsy were least likely to be treated (50.8%). Approximately 80% of those with other forms of epilepsy were treated at the time of diagnosis. Use of specific medications reflected current guidelines and recommendations for treatment of specific seizure types and syndromes. Conclusions: In Connecticut, approximately 20% of children with epilepsy are not treated at the time of initial diagnosis, and around 10% continue to be untreated after 1 year. This most likely reflects the increased understanding of the nature of pediatric epilepsy and concerns regarding the adverse effects of AEDs. The most commonly used first drugs are carbamazepine and valproate. Follow-up of this cohort may help provide information to guide the use of recently approved AEDs.
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页码:1267 / 1271
页数:5
相关论文
共 22 条
[1]   ANTIEPILEPTIC DRUG-TREATMENT OF BENIGN CHILDHOOD EPILEPSY WITH ROLANDIC SPIKES - IS IT NECESSARY [J].
AMBROSETTO, G ;
TASSINARI, CA .
EPILEPSIA, 1990, 31 (06) :802-805
[2]  
[Anonymous], 1981, Epilepsia, V22, P489
[3]  
[Anonymous], 1993, EPILEPSIA, V34, P592
[4]   PROPOSAL FOR REVISED CLASSIFICATION OF EPILEPSIES AND EPILEPTIC SYNDROMES [J].
不详 .
EPILEPSIA, 1989, 30 (04) :389-399
[5]   TREATMENT OF CHILDHOOD EPILEPSY [J].
APPLETON, RE .
PHARMACOLOGY & THERAPEUTICS, 1995, 67 (03) :419-431
[6]   Newly diagnosed epilepsy in children: Presentation at diagnosis [J].
Berg, AT ;
Shinnar, S ;
Levy, SR ;
Testa, FM .
EPILEPSIA, 1999, 40 (04) :445-452
[7]   Do seizures beget seizures? An assessment of the clinical evidence in humans [J].
Berg, AT ;
Shinnar, S .
JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 1997, 14 (02) :102-110
[8]  
Berg AT, 1995, CHILDHOOD SEIZURES, P1
[9]   Familial occurrence of epilepsy in children with newly diagnosed multiple seizures: Dutch study of epilepsy in childhood [J].
Callenbach, PMC ;
Geerts, AT ;
Arts, WFM ;
van Donselaar, CA ;
Peters, ACB ;
Stroink, H ;
Brouwer, OF .
EPILEPSIA, 1998, 39 (03) :331-336
[10]   Incidence of epilepsy in childhood and adolescence: A population-based study in Nova Scotia from 1977 to 1985 [J].
Camfield, CS ;
Camfield, PR ;
Gordon, K ;
Wirrell, E ;
Dooley, JM .
EPILEPSIA, 1996, 37 (01) :19-23