Casein kinase 1: A Wnt'er of disconnect

被引:127
作者
Polakis, P [1 ]
机构
[1] Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA
关键词
D O I
10.1016/S0960-9822(02)00969-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Phosphorylation of β-catenin, a central downstream component of the Wnt pathway, by glycogen synthase kinase 3 is essential for its targeted degradation by the proteosome. New studies show that casein kinase 1 primes β-catenin for subsequent phophorylation by glycogen synthase kinase 3.
引用
收藏
页码:R499 / R501
页数:3
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