Casein kinase 1: A Wnt'er of disconnect

被引：127

作者：

Polakis, P ^{[1
]}

机构：

[1] Genentech Inc, Dept Mol Oncol, San Francisco, CA 94080 USA

来源：

CURRENT BIOLOGY | 2002年 / 12卷 / 14期

关键词：

D O I：

10.1016/S0960-9822(02)00969-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phosphorylation of β-catenin, a central downstream component of the Wnt pathway, by glycogen synthase kinase 3 is essential for its targeted degradation by the proteosome. New studies show that casein kinase 1 primes β-catenin for subsequent phophorylation by glycogen synthase kinase 3.

引用

页码：R499 / R501

页数：3

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