Molecular and cell biology of Legionella pneumophila

被引:28
作者
Bitar, DM
Molmeret, M
Abu Kwaik, Y
机构
[1] Univ Louisville, Coll Med, Dept Microbiol & Immunol, Louisville, KY 40202 USA
[2] Univ Kentucky, Coll Med, Dept Microbiol & Immunol, Lexington, KY USA
[3] Al Quds Univ, Fac Med, Dept Microbiol, Jerusalem, Israel
[4] Al Quds Univ, Fac Med, Dept Med Microbiol & Immunol, Jerusalem, Israel
关键词
Dot/Icm; amoebae; intracellular; phagosome; lysosomes; egress; lgn1;
D O I
10.1078/1438-4221-00286
中图分类号
Q93 [微生物学];
学科分类号
071005 [微生物学]; 100705 [微生物与生化药学];
摘要
Legionella pneumopbila is a facultative intracellular pathogen that can replicate within phagocytic host cells such as protozoa and macrophages. Evasion of phagocytic killing is mediated by the type IV Dot/Icm secretion system, which exports bacterial effectors that modulate biogenesis of the phagosome to evade endocytic fusion and also to intercept vesicles derived from the endoplasmic reticulum. Bacterial replication is associated with activation of caspase-3 in infected macrophages and is culminated in apoptosis and pore formation-mediated cytolysis of the host.
引用
收藏
页码:519 / 527
页数:9
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