Bioenergetics of aging and calorie restriction

被引:48
作者
Hunt, Nicole D.
Hyun, Dong-Hoon
Allard, Joanne S.
Minor, Robin K.
Mattson, Mark P.
Ingram, Donald K.
de Cabo, Rafael
机构
[1] NIA, Lab Expt Gerontol, Gerontol Res Ctr, NIH, Baltimore, MD 21224 USA
[2] NIA, Lab Neurosci, NIH, Baltimore, MD 21224 USA
关键词
aging; calorie restriction; bioenergetics; oxidative damage;
D O I
10.1016/j.arr.2006.03.006
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Aging is a physiological process that involves a multi-factorial set of deleterious changes. These alterations are caused by an exponential increase in damage to macromolecules. This process is likely due to the cumulative effects of oxidative stress over time. One area of ongoing research in gerontology has focused on determining why there is an age-dependent decrease in cellular bioenergetics. The aim of this review is to summarize the recent findings on the effects of aging and calorie restriction on energy metabolism. The effect of calorie restriction on age-associated changes in bioenergetic parameters will be examined. Published by Elsevier Ireland Ltd.
引用
收藏
页码:125 / 143
页数:19
相关论文
共 155 条
[131]   STUDIES IN THE DISTRIBUTION OF BODY-FAT .1. EFFECTS OF AGE, SEX, AND OBESITY [J].
SHIMOKATA, H ;
TOBIN, JD ;
MULLER, DC ;
ELAHI, D ;
COON, PJ ;
ANDRES, R .
JOURNALS OF GERONTOLOGY, 1989, 44 (02) :M66-M75
[132]   A role for leptin in the antiaging action of dietary restriction: A hypothesis [J].
Shimokawa, I ;
Higami, Y .
AGING-CLINICAL AND EXPERIMENTAL RESEARCH, 1999, 11 (06) :380-382
[133]   LIPID COMPOSITIONS OF DIFFERENT REGIONS OF THE HUMAN-BRAIN DURING AGING [J].
SODERBERG, M ;
EDLUND, C ;
KRISTENSSON, K ;
DALLNER, G .
JOURNAL OF NEUROCHEMISTRY, 1990, 54 (02) :415-423
[134]   Oxidative stress, caloric restriction, and aging [J].
Sohal, RS ;
Weindruch, R .
SCIENCE, 1996, 273 (5271) :59-63
[135]   MITOCHONDRIAL SUPEROXIDE AND HYDROGEN-PEROXIDE GENERATION, PROTEIN OXIDATIVE DAMAGE, AND LONGEVITY IN DIFFERENT SPECIES OF FLIES [J].
SOHAL, RS ;
SOHAL, BH ;
ORR, WC .
FREE RADICAL BIOLOGY AND MEDICINE, 1995, 19 (04) :499-504
[136]   Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle [J].
Sreekumar, R ;
Unnikrishnan, J ;
Fu, A ;
Nygren, J ;
Short, KR ;
Schimke, J ;
Barazzoni, R ;
Nair, KS .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2002, 283 (01) :E38-E43
[137]   Mitochondrial creatine kinase is a prime target of peroxynitrite-induced modification and inactivation [J].
Stachowiak, O ;
Dolder, M ;
Wallimann, T ;
Richter, C .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (27) :16694-16699
[138]   Protein oxidation and aging [J].
Stadtman, Earl R. .
FREE RADICAL RESEARCH, 2006, 40 (12) :1250-1258
[139]   TRANSCRIPTIONAL REGULATOR OF OXIDATIVE STRESS-INDUCIBLE GENES - DIRECT ACTIVATION BY OXIDATION [J].
STORZ, G ;
TARTAGLIA, LA ;
AMES, BN .
SCIENCE, 1990, 248 (4952) :189-194
[140]   Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction [J].
Stuart, JA ;
Karahalil, B ;
Hogue, BA ;
Souza-Pinto, NC ;
Bohr, VA .
FASEB JOURNAL, 2004, 18 (01) :595-+