Silence of the centromeres - not

被引：6

作者：

Cooke, HJ ^{[1
]}

机构：

[1] Western Gen Hosp, MRC Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

TRENDS IN BIOTECHNOLOGY | 2004年 / 22卷 / 07期

关键词：

D O I：

10.1016/j.tibtech.2004.04.015

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Centromeres are a conundrum; although many proteins associated with centomeres are conserved from yeast to humans, the underlying DNA sequence is not. A proposed solution to this problem is that an epigenetic, largely heterochromatic, state be imposed by these proteins. Recent analysis of a human neocentromere and the complete sequence of a rice centromere suggest that this epigenetic state can enable transcription of at least some genes within a centromere.

引用

页码：319 / 321

页数：3

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