THE ROLE OF INHIBITION IN HUMAN MOTOR CORTICAL PLASTICITY

被引：50

作者：

Bachtiar, V. ^{[1
]}

Stagg, C. J. ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford Ctr Funct MRI Brain FMRIB, Oxford, England

来源：

NEUROSCIENCE | 2014年 / 278卷

基金：

英国惠康基金;

关键词：

GABA; motor; plasticity; stroke recovery; human; TRANSCRANIAL MAGNETIC STIMULATION; THETA-BURST STIMULATION; GAMMA-AMINOBUTYRIC-ACID; INTRACORTICAL INHIBITION; HUMAN BRAIN; HOMEOSTATIC PLASTICITY; RAPID MODULATION; IN-VIVO; RESONANCE-SPECTROSCOPY; MOVEMENT PREPARATION;

D O I：

10.1016/j.neuroscience.2014.07.059

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Over recent years evidence from animal studies strongly suggests that a decrease in local inhibitory signaling is necessary for synaptic plasticity to occur. However, the role of GABAergic modulation in human motor plasticity is less well understood. Here, we summarize the techniques available to quantify GABA in humans, before reviewing the existing evidence for the role of inhibitory signaling in human motor plasticity. Wediscuss a number of important outstanding questions that remain before the role of GABAergic modulation in long-term plasticity in humans, such as that underpinning recovery after stroke, can be established. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

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页码：93 / 104

页数：12

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