A lipophilic polyamino-bolaamphiphile designed to dissipate pH gradients across a bilayer membrane: Synthesis and proton transport

被引：18

作者：

Dubowchik, GM

Firestone, RA

机构：

[1] Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492-7660

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 36期

关键词：

D O I：

10.1016/0040-4039(96)01438-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A linear, bolaamphiphilic octaamine 5 containing eight adamantyl groups and two sulfonates as polar head groups was efficiently prepared from spermine. The compound is designed to span a bilayer membrane and dissipate a pH gradient by proton transfer along the backbone. Results from proton transport experiments using liposomes were consistent with design. Copyright (C) 1996 Elsevier Science Ltd

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页码：6465 / 6468

页数：4

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