Efficient palladium(II)-mediated construction of functionalized plakortone cores

被引:30
作者
Paddon-Jones, GC [1 ]
Hungerford, NL [1 ]
Hayes, P [1 ]
Kitching, W [1 ]
机构
[1] Univ Queensland, Dept Chem, Brisbane, Qld 4072, Australia
关键词
D O I
10.1021/ol991055c
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] Appropriate enediols experience a one-pot palladium(II)-mediated hydroxycyclization-carbonylation-lactonization sequence to provide sidechain-functionalized 2,6-dioxabicyclo[3.3.0]octan-3-ones, the core structures of the plakortones, a novel class of activators of cardiac SR-Ca2+-pumping ATPase, from the sponge Plakortis halichondrioides.
引用
收藏
页码:1905 / 1907
页数:3
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